Publications

2014

  1. Andreev OA, Engelman DM and Reshetnyak YK (2014) “Targeting diseased tissues by pHLIP insertion at low cell surface pH.” Front. Physiol. 5:97. doi: 10.3389/fphys.2014.00097
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  2. Cruz-Monserrate, Z. et al. Targeting Pancreatic Ductal Adenocarcinoma Acidic Microenvironment. Sci. Rep. 4, 4410; DOI:10.1038/srep04410 (2014).
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2013

  1. Dhammika Weerakkody, Anna Moshnikova, Mak S. Thakur, Valentina Moshnikova, Jennifer Daniels, Donald M. Engelman, Oleg A. Andreev, and Yana K. Reshetnyak, “Family of pH (low) insertion peptides for tumor targeting,” PNAS, Vol 110, No. 15 pp. 5834-5839, 2013.
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  2. Lan Yao, Jennifer Daniels, Dayanjali Wijesinghe, Oleg A. Andreev, Yana K. Reshetnyak, “pHLIP Mediated Delivery of PEGylated Liposomes to Cancer Cells,” Journal of Controlled Release, Vol 167, pp. 228-237, 2013.
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  3. Anna Moshnikova, Valentina Moshnikova, Oleg A. Andreev, Yana K. Reshetnyak, “Antiproliferative Effect of pHLIP-Amanitin,” Biochemistry, Vol 57, No. 7, pp. 1171-1178, 2013.
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  4. Eugene A. Sosunova, Evgeny P. Anyukhovsky, Alexander A. Sosunov, Anna Moshnikova, Dayanjali Wijesinghe, Donald M. Engelmand, Yana K. Reshetnyak, and Oleg A. Andreev, “pH (low) insertion peptide (pHLIP) targets ischemic myocardium,” PNAS, Vol 110, No. 1, pp. 82-86, 2013.
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  5. Lan Yao, Jennifer Danniels, Anna Moshnikova, Sergey Kuznetsov, Aftab Ahmed, Donald M. Engelman, Yana K. Reshetnyak, and Oleg A. Andreev, “pHLIP peptide targets nanogold particles to tumors,” PNAS, Vol 110, No. 2, pp. 465-470, 2013.
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  6. Wijesinghe, D., Arachchige, M.C.M., Lu, A., Reshetnyak, Y.K. & Andreev, O.A. pH dependent transfer of nano-pores into membrane of cancer cells to induce apoptosis. Sci. Rep., 3, 3560; DOI: 10.1038/srep03560 (2013).
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2012

  1. Yana K. Reshetnyak, Cynthia N. Prudence, James Segala, Vladislav S. Markin, Oleg A. Andreev, “Parking problem and negative cooperativity of binding of myosin subfragment 1 to F-actin,” Biochemical and Biophysical Research Communications, Vol. 425, pp. 476-479, 2012.
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  2. Pierre Daumar, Cindy Wanger-Baumann, Nagavara Pillarsetty, Laura A Fabrizio, Sean D Carlin, Yana K. Reshetnyak, Oleg A. Andreev, and Jason S. Lewis, “Efficient [18F]-Labeling of Large 37-Amino Acid pHLIP Peptide Analogues and their Biological Evaluation,” Bioconjugate Chemistry, pp. 1-45, 2012.
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  3. Alexander G. Karabadzhak, Dhammika Weerakkody, Dayanjali Wijesinghe, Mak S. Thakur, Donald M. Engelman, Oleg A. Andreev, Vladislav S. Markin, and Yana K. Reshetnyak, “Modulation of the pHLIP Transmembrane Helix Insertion Pathway,” Biophysical Journal, vol. 102, pp. 1846-1855, 2012.
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  4. Sven Macholl, Matthew S. Morrison, Peter Iveson, Bente E. Arbo, Oleg A. Andreev, Yana K. Reshetnyak, Donald M. Engelman, Edvin Johannesen, “In Vivo pH Imaging with 99mTc-pHLIP,” Molecular Imaging Biology, vol. 14, pp. 725-734, 2012.
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2011

  1. Francisco N. Barrera, Dhammika Weerakkody, Michael Anderson, Oleg A. Andreev, Yana K. Reshetnyak and Donald M. Engelman, "Roles of Carboxyl Groups in the Transmembrane Insertion of Peptides," Journal of Molecular Biology, vol. 413, pp. 359-371, 2011.
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  2. Y. K. Reshetnyak, L. Yao, S. Zheng, S. Kuznetsov, D. M. Engelman and O. A. Andreev, "Measuring Tumor Aggressiveness and Targeting Metastatic Lesions with Fluorescent pHLIP," Mol Imaging Biol, vol. 13, pp. 1146-1156, 2011.
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  3. Dayanjali Wijesinghe, Donald M. Engelman, Oleg A. Andreev, and Yana K. Reshetnyak, "Tuning a Polar Molecule for Selective Cytoplasmic Delivery by a pH(Low) Insertion Peptide," Biochemistry, vol. 50, pp. 10215-10222, 2011.
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  4. Cynthia N. Prudence, Brad Boudreau, Yana K. Reshetnyak, "Protein Fluorescence Database," Recent Researches in Chemistry, Biology, Environment and Culture, pp. 59-63, 2011.
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2010

  1. M. An, D. Wijesinghe, O. A. Andreev, Y. K. Reshetnyak and D. M. Engelman, "pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation," Proc Natl Acad Sci U S A, vol. 107, no. 47, pp. 20246-50, 2010.
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  2. O. A. Andreev, A. G. Karabadzhak, D. Weerakkody, G. O. Andreev, D. M. Engelman and Y. K. Reshetnyak, "pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path," Proc Natl Acad Sci U S A, vol. 107, no. 9, pp. 4081-6, 2010.
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  3. O. A. Andreev, D. M. Engelman and Y. K. Reshetnyak, "pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents," Mol Membr Biol, vol. 27, no. 7, pp. 341-52, 2010.
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  4. M. Musial-Siwek, A. Karabadzhak, O. A. Andreev, Y. K. Reshetnyak and D. M. Engelman, "Tuning the insertion properties of pHLIP," Biochim Biophys Acta, vol. 1798, no. 6, pp. 1041-6, 2010.
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  5. L. Yao, J. Segala, A.J. Bucci, G.O. Andreev, Y.K. Reshetnyak, and O.A. Andreev, "Fluorescence anistrophy imaging microscopy," Microscopy: Science, Technology, Applications and Education, Formatex Research Center, 3, pp. 2072-8, 2010.
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2009

  1. O. A. Andreev, D. M. Engelman and Y. K. Reshetnyak, "Targeting acidic diseased tissue: New technology based on use of the pH (Low) Insertion Peptide (pHLIP)," Chemistry Today, vol. 27, no. 2, pp. 34-37, 2009.
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  2. J. Hixon, and Y. K. Reshetnyak, "Algorithm for the Analysis of Tryptophan Fluorescence Spectra and Their Correlation with Protein Structural Parameters," Algorithms, vol. 2, pp. 1155-76, 2009.
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  3. J. Segala, D. M. Engelman, Y. K. Reshetnyak and O. A. Andreev, "Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP)," Int J Mol Sci, vol. 10, no. 8, pp. 3478-87, 2009.
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  4. A. L. Vavere, G. B. Biddlecombe, W. M. Spees, J. R. Garbow, D. Wijesinghe, O. A. Andreev, D. M. Engelman, Y. K. Reshetnyak and J. S. Lewis, "A novel technology for the imaging of acidic prostate tumors by positron emission tomography," Cancer Res, vol. 69, no. 10, pp. 4510-6, 2009.
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  5. L. Yao, G. O. Andreev, Y. K. Reshetnyak and O. A. Andreev, "Fabrication of semiconductor nanowires by conjugation of quantum dots to actin filaments," Anal Bioanal Chem, vol. 395, no. 5, pp. 1563-6, 2009.
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2008

  1. N. Jain, Y. K. Reshetnyak, L. Gao, M. P. Chiarelli and B. P. Cho, "Fluorescence probing of aminofluorene-induced conformational heterogeneity in DNA duplexes," Chem Res Toxicol, vol. 21, no. 2, pp. 445-52, 2008.
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  2. Y. K. Reshetnyak, O. A. Andreev, M. Segala, V. S. Markin and D. M. Engelman, "Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane," Proc Natl Acad Sci U S A, vol. 105, no. 40, pp. 15340-5, 2008.
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  3. C. Shen, R. Menon, D. Das, N. Bansal, N. Nahar, N. Guduru, S. Jaegle, J. Peckham and Y. K. Reshetnyak, "The protein fluorescence and structural toolkit: Database and programs for the analysis of protein fluorescence and structural data," Proteins, vol. 71, no. 4, pp. 1744-54, 2008.
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  4. M. Zoonens, Y. K. Reshetnyak and D. M. Engelman, "Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors," Biophys J, vol. 95, no. 1, pp. 225-35, 2008.
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2007

  1. O. A. Andreev, A. D. Dupuy, M. Segala, S. Sandugu, D. A. Serra, C. O. Chichester, D. M. Engelman and Y. K. Reshetnyak, "Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo," Proc Natl Acad Sci U S A, vol. 104, no. 19, pp. 7893-8, 2007.
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  2. O. A. Andreev and Y. K. Reshetnyak, "Mechanism of formation of actomyosin interface," J Mol Biol, vol. 365, no. 3, pp. 551-4, 2007.
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  3. Y. K. Reshetnyak, M. Segala, O. A. Andreev and D. M. Engelman, "A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers," Biophys J, vol. 93, no. 7, pp. 2363-72, 2007.
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  4. M. Torrent, E. Cuyas, E. Carreras, S. Navarro, O. Lopez, A. de la Maza, M. V. Nogues, Y. K. Reshetnyak and E. Boix, "Topography studies on the membrane interaction mechanism of the eosinophil cationic protein," Biochemistry, vol. 46, no. 3, pp. 720-33, 2007.
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2006

  1. O. A. Andreev, S. Sandugu, D. M. Engelman, and Y. K. Reshetnyak "Injection of Molecules into cells using a pH-triggered molecular nanosyringe," Technical Proceed. of the 2006 Nanotech Conf., vol. 2, pp. 57-60, 2006.
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  2. Y. K. Reshetnyak, O. A. Andreev, U. Lehnert and D. M. Engelman, "Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix," Proc Natl Acad Sci U S A, vol. 103, no. 17, pp. 6460-5, 2006.
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  3. Y. Reshetnyak, K. T. Tchedre, M. P. Nair, P. H. Pritchard and A. G. Lacko, "Structural differences between wild-type and fish eye disease mutant of lecithin:cholesterol acyltransferase," J Biomol Struct Dyn, vol. 24, no. 1, pp. 75-82, 2006.
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2004

  1. D. Linke, J. Frank, M. S. Pope, J. Soll, I. Ilkavets, P. Fromme, E. A. Burstein, and Y. Reshetnyak, "Folding Kinetics and Structure of OEP16," Biophys.J., vol. 86, no. 3, pp. 1479-1487, 2004.
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  2. Y.K. Reshetnyak, R. P. Kitson, M. Lu, and R. H. Goldfarb, "Conformational and enzymatic changes of 20S proteasome of rat natural killer cells induced by mono and divalent cations," J. Struct. Biol., vol. 145, no. 3, pp. 263-71, 2004.
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